Many guys have favorite parts of the female body. Me personally, I'm one who appreciates a beautiful smile and part of it comes from the twinkle in her eyes, hence the title of the song. Notice the lack of sexual innuendo throughout the song. The way the song is written, guys can repeat select lines from this song to a girl and not get slapped, which is what would happen if they tried to talk to a girl using lyrics from many rap songs today. I’m referring to a girl with self-confidence and a sense of self-respect; any female who responds to a 50 Cent quote is probably not worth your time. This song toward the end not only switches keys but features a talkbox solo.