sound.
New Technology goes through three stages:
First it is ridiculed by those ignorant of its potential
Next, it is subverted by those threatened by its potential
Finally, it is considered self-evident.
Autechre, Funkstorung, Prefuse 73, New York Dolls, Miles Davis, Daniel Myer, Rapture, Beastie Boys, Lush Jackson, Cibo Mato, Janes Addiction, Tribe etc....
To many come to mind.
Software and live instruments